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Research & review articles

Peer-reviewed journal articles

These peer-reviewed journal articles report on recent, high-impact hypoglycaemia research and provide up-to-date information on hypoglycaemia risk factors, consequences, and management strategies.


Validation of a Hypoglycemia Risk Stratification Tool Using Data From Continuous Glucose Monitors
Karter et al
JAMA Network Open 2023; 6:e236315
Access the tool here to calculate hypoglycemia risk and here is a summary on how to use this tool

Redefining Hypoglycemia in Clinical Trials: Validation of Definitions Recently Adopted by the American Diabetes Association/European Association for the Study of Diabetes
Heller SR et al
Diabetes Care. 2019 Oct 28. pii: dc182361. doi: 10.2337/dc18-236

Satisfaction with the Use of Different Technologies for Insulin Delivery and Glucose Monitoring Among Adults with Long-Standing Type 1 Diabetes and Problematic Hypoglycemia: 2-Year Follow-Up in the HypoCOMPaSS Randomized Clinical Trial
Speight J et al
Diabetes Technology and Therapeutics;21:619

Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management
The International Hypoglycaemia Study Group
Lancet Diabetes & Endocrinology 2019; 7:385

The role of structured education in the management of hypoglycaemia
Iqbal A
Diabetologia 2017; DOI 10.1007/s00125-017-4334-z

Novel glucose-sensing technology and hypoglycaemia in T1D
Bolinder J
Lancet 2016; 388:2254

Association between severe hypoglycemia and CVD risk in Japanese patients with T2D
Goto A
J Am Heart Assoc 2016; 5:e002875

Severe hypoglycaemia in adults with insulin-treated diabetes: impact on health resources
Heller S
Diabet Med 2016; 33:471

Phase 3 trial of transplantation of human islets in T1D complicated by severe hypoglycemia
Hering BJ
Diabetes Care 2016;39:1230

Effects of sleep deprivation on hypoglycaemia-induced cognitive impairment and recovery in adults with T1D
Inkster BE
Diabetes Care 2016;39:750

A population-based study of all-cause mortality and CVD in association with prior history of hypoglycemia among patients with T1D
Diabetes Care  2016;39:1571

IAH in adults with T1D is not associated with autonomic dysfunction or peripheral neuropathy
Olsen SE
Diabetes Care 2016;39:426

Intranasal glucagon for treatment of insulin-induced hypoglycemia in patients with T1D
Rickels MR
Diabetes Care 2016;39:264

Continuous glucose monitoring for patients with T1D and IAH: IN CONTROL
Van Beers CAJ
Lancet Diabet Endocrinol 2016;4:893

Risk factors associated with severe hypoglycemia in older adults with T1D
Weinstock RS
Diabetes Care 2016;39:603

Minimizing hypoglycemia in diabetes
Cryer P
Diabetes Care 2015;38:1583

Evidence-Informed Clinical Practice Recommendations for Treatment of Type 1 Diabetes Complicated by Problematic Hypoglycemia
Choudhary P
Diabetes Care 2015;38:1016–1029

Interventions That Restore Awareness of Hypoglycemia in Adults With Type 1 Diabetes: A Systematic Review and Meta-analysis
Yeoh E
Diabetes Care. 2015 Aug;38(8):1592-609

Glycemic goals in diabetes
Cryer P
Diabetes 2014; 63:2188

Strategies to limit the effect of hypoglycaemia
Childs B
Clinical Diabetes 2012;30:28

* CVD = cardiovascular disease; T1D = type 1 diabetes; T2D = type 2 diabetes.